Syphilis - a higher incidence of leukoplakia seen in patients with syphilic glossitis- tongue becomes stiff and frequently has extensive dorsal leukoplakia. Etiology &pathogenesis 24. Sunlight: UV radiation from sun rays - leukoplakia development at vermillion border of lower lips and associated with actinic chelitis Neoplasia-2 Etiology and pathogenesis of cancer S. Parasuraman Faculty of Pharmacy AIMST University. 2. Cancer incidence • World wide cancer related death - 20 % • In US- cancer is second most common cause of death • Most common cancer in developed countries are lung, breast, prostate and colorectal • Most common cancer in developing. Basic mechanisms involved in the pathogenesis of OSF can be divided into four steps: 1. Occurrence of the chronic inflammation at the site of betel quid placement 2. Increased collagen synthesis 3. Collagen cross-linking 4. Decreased collagen degradation 53. 1. Occurrence of the chronic inflammation at the site of betel quid placement: 54. 1 Leukoplakia is a condition in which one or more white patches or spots (lesions) forms inside the mouth. Leukoplakia is different from other causes of white patches such as thrush or lichen planus because it can eventually develop into oral cancer. Within 15 years, about 3% to 17.5% of people with leukoplakia will develop squamous cell. Introduction. Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia that was first described in 1985. 1 It can manifest as a multifocal, oral white plaque that transforms to verrucous and invasive oral squamous cell carcinoma (SCC) in 40% - 70% of cases.1, 2 Additional clinical characteristics include a strong tendency to recur after excision, and a notable absence of.
Leukoplakia with dysplasia exhibits characteristic architectural and cytological features of keratinizing dysplasia. Features include hyperkeratosis / parakeratosis, epithelial atrophy or hyperplasia with bulbous rete ridges, basal cell hyperplasia with nuclear hyperchromasia or increased nuclear cytoplasmic ratio, variable suprabasal or atypical mitoses, dyskeratosis or glassy cytoplasm. Proliferative verrucous leukoplakia (PVL) is a potentially premalignant lesion that undergoes malignant transformation in over 40% of cases. Its clinical homogeneity suggests that a single or a small number of molecular pathogenic pathways may exist Leukoplakia of the oral mucosa is characterized by impairment of the epithelial differentiation program. The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of immune effectors. The clinical effect manifested in involution or shrinkage and loosening of the. 3. HIV PATHOGENESIS When HIV infects a cell, it first attaches to and fuses with host cell. Then the viral RNA is converted into DNA and virus uses the host cell's machinery to replicate itself during a process called reverse transcription. The new copies of HIV then leave the host cell and move on to infect cells.kli 17
Pathogenesis of leukoplakia has been thought to be characterized by impairment of the epithelial differentiation program . Loss of heterozygosity, mutation of p53 gene, mitochondrial genomic. Pathogenesis of Leukoplakia A better understanding of the molecular biology of cancer development is the only way to optimize our chances of predicting the oncogenic potential of leukoplakia. Recently, molecular biology studies have found that a variable percentage of oral leukoplakias are associated with molecular abnormalities also found.
Among 11 leukoplakia patients with an OCRI2 over 0.5, 4 (36.4%) developed cancer during follow-up (23 ± 20 months), whereas 3 (5.3%) of 57 leukoplakia patients with an OCRI2 less than 0.5. Oral leukoplakia (OL) is a white patch or plaque that cannot be rubbed off, cannot be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco. Therefore, a process of exclusion establishes the diagnosis of the disease PATHOGENESIS. OLP is a T-cell mediated autoimmune disease in which the auto-cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. An early event in the disease mechanism involves keratinocyte antigen expression or unmasking of an antigen that may be a self-peptide or a heat shock protein.[1,6] Following this, T cells (mostly CD8+, and some CD4+ cells) migrate. Oral leukoplakia is the most common potentially malignant lesion defined as a predominantly white lesion of oral mucosa that cannot be characterised as any other definable lesion. The appearance of leukoplakia varies from uniformly white homogeneous lesions (Fig 5) to non-homogeneous speckled lesions with red and/or nodular features (Fig 6) Oral leukoplakia, as traditionally defined by the World Health Organization (WHO), is a predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion. Kramer IR, Lucas RB, Pindborg JJ, et al. Definition of leukoplakia and related lesions: an aid to studies on oral precancer
Leukoplakia treatment is most successful when a lesion is found and treated early, when it's small. Regular checkups are important, as is routinely inspecting your mouth for areas that don't look normal. For most people, removing the source of irritation ― such as stopping tobacco or alcohol ― clears the condition . Examination early in the disease process may reveal isolated areas of leukokeratosis, sometimes with adjacent erythematous mucosa, as demonstrated in the image below. Individual lesions may progress from.
A large number of oral carcinomas are associated with precursor lesions of leukoplakia; 3 to 6% of leukoplakias undergo malignant transformation, with this frequency increasing with longer follow-up periods. 23,24 The presence or absence of malignant change in a lesion of oral mucosal leukoplakia cannot be reliably determined by visual examination Oral hairy leukoplakia (OHL) is a disease of the mucosa first described in 1984. This pathology is associated with Epstein-Barr virus (EBV) and occurs mostly in people with HIV, both immunocompromised and immunocompetent, albeit it can affect patients who are HIV negative schematic model for the pathogenesis of candidal leukoplakia. wherein occlusal friction acts as a co-factor leading to the initial. oral keratosis. Since it is a common observation that most com Hairy Leukoplakia Definition Hairy leukoplakia is one of the most common and characteristic lesions of human immunodeficiency virus (HIV) infection. Rarely, it can also appear in immunosuppressed patients after organ transplantation. Etiology Epstein-Barr virus seems to play an important role in the pathogenesis SlideShare Explorar Pesquisar Voc Nystatin therapy- it is given in candidal leukoplakia 500,000 IU twice daily plus mouth rinses with chlorhexidine solution Vitamin B complex- it is given as a supplement in cases of Etiology & pathogenesis •Both antigen-specific & non-specific mechanisms may be involved in pathogenesis of OLP.
Leukoplakia appears as thick, white patches on the inside surfaces of your mouth. It has a number of possible causes, including repeated injury or irritation. It can also be a sign of precancerous changes in the mouth or mouth cancer. With leukoplakia (loo-koh-PLAY-key-uh), thickened, white patches form on your gums, the insides of your cheeks. Neoplasia-2 Etiology and pathogenesis of cancer S. Parasuraman Faculty of Pharmacy AIMST University 2. Cancer incidence • World wide cancer related death - 20 % • In US- cancer is second most common cause of death • Most common cancer in developed countries are lung, breast, prostate and colorectal • Most common cancer in developing. Chart and Diagram Slides for PowerPoint - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 1978;46:518-39. 19. Banoczy J, Csiba A. Occurrence of epithelial dysplasia in oral leukoplakia. Oral Surg Oral Med Oral Pathol 1976;42:766-74. 20. Roodenburg JLN, Panders AK, Vermey A. Carbon dioxide laser surgery of oral leukoplakia
With these concepts in mind, this chapter details the etiology, pathogenesis, clinical presentation, pathological features, and management approaches of OPMD and OSCC. Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978;46(4):518-39. PubMed CrossRef Google Scholar Head and neck cancer refers to malignancies of the oral cavity, pharynx, larynx, paranasal sinuses, nasal cavity or salivary glands. Alcohol and tobacco use account for the majority of head and neck cancers. Suspected cases require a biopsy of the lesion, typically followed by a staging CT scan of the neck and chest Vulvar cancer is a type of cancer that occurs on the outer surface area of the female genitalia. The vulva is the area of skin that surrounds the urethra and vagina, including the clitoris and labia. Vulvar cancer commonly forms as a lump or sore on the vulva that often causes itching. Though it can occur at any age, vulvar cancer is most.
Hairy leukoplakia. Hairy leukoplakia is a type of leukoplakia caused by the Epstein-Barr virus. You may have this type if you have a weakened immune system - for example, you have HIV or have had an organ transplant.. It causes fuzzy white patches, often on the sides of the tongue, that look folded or ridged Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida
Evidence suggests that there is a role for one or more of HPV16, 18, and possibly 31, 33 in the pathogenesis of some oral squamous cell carcinomas. RNA Viruses: A. PICORNA VIRUS: COXSACKIE • Picornavirus. • Coxsackie A viruses cause herpangina, hand foot and mouth disease, and acute lymphonodular pharyngitis White sponge nevus is a rare, benign condition inherited as an autosomal dominant trait. Typical lesions are asymptomatic white plaques in which the oral mucosa appears thickened and folded, with a spongy texture (Figs 27-6 and 29-10 ). The most common location for a white sponge nevus is on the buccal mucosa, often in a bilateral distribution Leukoplakia is estimated to undergo malignant transformation at a rate ranging between 1 and 17.5% per year, 9, 40, 44, 110 and is typically managed either by follow-up or excision of the lesion depending on histological assessment of dysplasia severity Caused by Rhinosporidium seeberi, traditionally thought to be a fungus but actually an aquatic protistan parasite (J Clin Microbiol 1999;37:2750) ; Endemic in southern India, Sri Lanka and emigrants from this region (Diagn Pathol 2006;1:25, Singapore Med J 2004;45:224); rare indigenous cases in U.S. (South Med J 1996;89:65) Natural aquatic habitat, transmitted through traumatized epithelium.
Oral lichen planus (LIE-kun PLAY-nus) is an ongoing (chronic) inflammatory condition that affects mucous membranes inside your mouth. Oral lichen planus may appear as white, lacy patches; red, swollen tissues; or open sores. These lesions may cause burning, pain or other discomfort. Oral lichen planus can't be passed from one person to another Pathophysiology. Nocturnal parafunctional habits, such as bruxism (ie, grinding of the teeth) and thumb sucking, may be associated with the development of traumatic ulcers of the buccal mucosa, the labial mucosa, the lateral borders of the tongue, and the palate. In addition, local irritants such as fractured or malposed teeth and ill-fitting. Leukoplakia and erythroplakia are terms used to describe certain types of tissue changes that can be seen in the mouth or throat: Leukoplakia is a white or gray area that does not come off when scraped. Erythroplakia is a flat or slightly raised, red area that often bleeds easily if it's scraped Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, and is only named that because it looks like one. It is characterized by polygonal, flat-topped, violaceous papules and plaques with overlying, reticulated, fine white scale (Wickham's striae), commonly affecting dorsal hands, flexural.
HIV-related oral conditions occur in a large proportion of patients, and frequently are misdiagnosed or inadequately treated. Dental expertise is necessary for appropriate management of oral manifestations of HIV infection or AIDS, but many patients do not receive adequate dental care. Common or not Oral cancers develop on the tongue, the tissue lining the mouth and gums, under the tongue, at the base of the tongue, and the area of the throat at the back of the mouth. Oral cancer accounts for roughly three percent of all cancers diagnosed annually in the United States, or about 53,000 new cases each year
Molecular Pathogenesis of Oral Cancer. Oral carcinogenesis like any other cancer is a progressive disease and normal epithelium passes through stages starting from dysplasia to finally transforming into invasive phenotypes. Although all types of carcinomas are seen in oral cavity, the most common form of OC is squamous cell carcinoma Ludwig's angina (lat.: Angina ludovici) is a type of severe cellulitis involving the floor of the mouth. Early on the floor of the mouth is raised and there is difficulty swallowing saliva, which may run from the person's mouth. As the condition worsens, the airway may be compromised with hardening of the spaces on both sides of the tongue. This condition has a rapid onset over hours Carcinoma in situ of the oral cavity is found in less than 1% of men under 30 years of age. Up to 8% of men over 70 years of age and 2% of women over 70 years of age have carcinoma in situ of the oral cavity. It is rare before age 30 and peaks after 50 years. Non-smokers are likely to present at an older age Hepatosplenomegaly (HPM) is a disorder where both the liver and spleen swell beyond their normal size, due to one of a number of causes. The name of this condition — hepatosplenomegaly — comes. Oral leukoplakia is a precancerous lesion of the oral mucosa. The upregulation of Ki67 and cyclooxygenase-2 has been reported in both dysplastic and non-dysplastic tissues
Diagnosis. Your doctor makes a diagnosis of oral lichen planus based on: Discussion of your medical and dental history and the medications you're taking. Review of symptoms, including lesions in your mouth and any other places on your body. Examination of your mouth, and other areas as appropriate. He or she also may request lab tests such as If leukoplakia is found, cells taken from the patches are also checked under the microscope for signs of cancer. Exfoliative cytology: A procedure to collect cells from the lip or oral cavity. A piece of cotton, a brush, or a small wooden stick is used to gently scrape cells from the lips, tongue, mouth, or throat Oral Manifestations Of Systemic Diseases. Published by Howard Harrington Modified over 2 years ago Presentation on theme: ORAL MANIFESTATIONS OF SYSTEMIC DISEASES Presentation transcript: 1 ORAL MANIFESTATIONS OF SYSTEMIC DISEASES 2 INTRODUCTION Many patients suffering from diseases which may affect the whole body may show specific oral signs and symptoms Those with important oral signs are.
Oral squamous cell carcinoma affects about 34,000 people in the US each year. In the US, 3% of cancers in men and 2% in women are oral squamous cell carcinomas, most of which occur after age 50. As with most head and neck sites, squamous cell carcinoma is the most common oral cancer. The chief risk factors for oral squamous cell carcinoma are Erythroplakia is seen much less commonly than its white lesion counterpart, leukoplakia. A strong association with tobacco consumption and use of alcohol has been noted. In comparison with leukoplakia, it should, however, be viewed as a more serious lesion because of the significantly higher percentage of malignancies associated with it (Box 4-1) Leukoplakia & Progressive Multifocal Leukoencephalopathy Symptom Checker: Possible causes include Congenital AIDS. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search
The literature search revealed very little information on the pathogenesis and prognosis of this condition due to its rare occurrence. [researchonline.jcu.edu.au] Prognosis Non-muscle invasive bladder cancer has a good prognosis, with 5-year survival rates of 82-100%. [slideshare.net Oral hairy leukoplakia Pulmonary tuberculosis within the past year Severe bacterial infections (i.e. pneumonia, pyomyositis) And/or performance scale 3: bedridden <50% of the day during the last month Clinical stage IV HIV wasting syndrome, as defined by the Centers for Disease Control and Prevention a Pneumocystis carinii pneumoni Frey's syndrome (also known as Baillarger's syndrome, Dupuy's syndrome, auriculotemporal syndrome, or Frey-Baillarger syndrome) is a rare neurological disorder resulting from damage to or near the parotid glands responsible for making saliva, and from damage to the auriculotemporal nerve often from surgery.. The symptoms of Frey's syndrome are redness and sweating on the cheek area adjacent.
Penile Leukoplakia (Balanitis Xerotica Obliterans): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. [slideshare.net] However, meatus in 4-37% with involvement of urethra in about 20% Etiology and Pathophysiology The exact cause of BXO is unknown TTuummoorrss wwiitthh mmiixxeedd ddiiffffeerreennttiiaattiioonn mixed tumors: e.g. pleomorphic adenoma of salivary gland carcinosarcom Leukoplakia, or white and gray patches inside the mouth, may be caused by irritation. Or, the condition may be a sign of oral cancer. Learn more from WebMD about how leukoplakia is treated
clinically resembles leukoplakia but which has a multifocal distribution. These plaque-like lesions can range in presentation from smooth, ﬂat areas to irregular, elevated areas. This variant is commonly found on the dorsum of the tongue (Fig. 3) and on the buccal mucosa. Both the reticular form and its plaque-like variant are usually. Leukoplakia and erythroplakia (25). TUBERCULOSIS Tuberculosis (TB) is a chronic infectious granulomatous disease caused mainly by Mycobacterium tuberculosis, an acid-fast bacillus that is transmitted primarily through the Pathogenesis of the oral tuberculosis is self inoculation with infected sputum, the patient wit World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Winner of the Standing Ovation Award for Best PowerPoint Templates from Presentations Magazine. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect 30 Best Inspiratonal Cervical Cancer Quotes - 30 Best Inspiratonal Cervical Cancer Quotes According to American Cancer Society, there will be approx 13,170 new cases of invasive cervical cancer will be diagnosed. The news of cancer diagnosis can leave anyone in absolute shock and pain. But one should not leave their hope and belief behind as there are many cervical cancer survivors out there. pathogenesis. This review highlights the important aspects of the psychosomatic diseases affecting oral cavity. The review article has been prepared doing a literature review from the text books, World Wide Web and pubmed/medline. Key words: Psychosomatic disorders, Oro-mucosal diseases, Psyche, Soma, Emotional factors. Review ARticl
Pathophysiology. Osteoarthritis is traditionally thought of as a 'wear and tear' disease which occurs as we age.However, recent research suggests otherwise. The pathogenesis of OA involves a degradation of cartilage and remodelling of bone due to an active response of chondrocytes in the articular cartilage and the inflammatory cells in the surrounding tissues Epidemiology. Oral candidosis is frequent in the extremes of age (Akpan and Morgan, 2002).Approximately 5-7% of infants develop oral candidiasis. Its prevalence in AIDS patients is estimated to be 9-31% and close to 20% in the cancer patients (Lalla et al., 2013).The oral carriage of candida organisms is reported to be 30-45% in the general healthy adult population (Akpan and Morgan, 2002) An aneurysm is a weakening and bulging of an artery wall. Many have no symptoms and are not dangerous. However, at their most severe, aneurysms can lead to life-threatening internal bleeding Other factors are oral cancer/leukoplakia and a high carbohy-drate diet. Growth of candida in saliva is enhanced by the presence of glucose and its adherence to oral epithelial cells is enhanced by a high carbohydrate diet.43 Systemic factors Extremes of life predispose to infection because of reduced immunity. Vidian nerve is formed at the junction of greater petrosal and deep petrosal nerves. This area is located in the cartilagenous substance which fills the foramen lacerum. From this area it passes forward through the pterygoid canal accompanied by artery of pterygoid canal. It is here the ascending branch from the otic ganglion joins this nerve
Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. This can be obtained thanks to specific knowledge of oral manifestations of autoimmune. White patches of the oral mucosa are common and may represent a benign disorder (e.g. frictional keratosis), an oral potentially malignant disorder (e.g. leukoplakia), or malignancy (e.g. squamous cell carcinoma). 1 Given the high-risk nature of some white patches, it is important to perform a thorough history and examination.A surgical sieve approach can then be used to classify the lesions. By definition, a dentigerous cyst occurs in association with an unerupted tooth. Most commonly around permanent mandibular third molars (wisdom teeth) Somewhat less common around permanent maxillary third molars, maxillary cuspids and mandibular second premolars but any tooth may be involved
The pathogenesis of VC of the oral cavity is not clear. HPV, chewing tobacco, alcohol use, use of snuff, and poor oral hygiene are predisposing factors for the development of VC of the oral cavity.[8,9,10] HPV types six and 11 are the most common pathogens for oral squamous papillomas, but there is controversy regarding its viral origin Cervical ectropion occurs when there is eversion of the endocervix, exposing the columnar epithelium to the vaginal milieu. It is also known as a cervical erosion, although no erosion of cells actually occurs. It is a benign condition, which is commonly seen on examination of the cervix in adolescents, in pregnancy, and in women taking oestrogen containing contraceptives Peritonsillar abscess is the most common deep infection of the head and neck, with an annual incidence of 30 cases per 100,000 persons in the United States.1 - 3 This infection can occur in all.
Definition . Systemic Lupus Erythematosus is chronic inflammatory multisystem disease of unknown etiology. It is an autoimmune disease where body's immune system (antibodies in this case referred to as autoantibodies) mistakenly attacks its own tissues, causing multi-organ inflammation and diverse clinical manifestations with domination of peripheral symmetric polyarthritis of small and. Cutaneous vasculitis is a group of disorders in which there are inflamed blood vessels in the skin. These may include capillaries, venules, arterioles and lymphatics. Cutaneous vasculitis has several different causes. There are a wide variety of clinical presentations. It is associated with systemic vasculitis in a minority of patients Periapical periodontitis or apical periodontitis (AP) is an acute or chronic inflammatory lesion around the apex of a tooth root, most commonly caused by bacterial invasion of the pulp of the tooth. It is a likely outcome of untreated dental caries (tooth decay), and in such cases it can be considered a sequela in the natural history of tooth decay, irreversible pulpitis and pulpal necrosis Cervical cancer is the third most common cause of death due to a gynecological. malignancy. after. endometrial. and. ovarian cancer. . Mortality is highest in individuals aged 55-64 years. One in 161 female individuals in the US ( ∼ 0.6%) will develop cervical cancer during their lifetime Arsenic is highly toxic and can enter the body through the gastrointestinal tract, skin or lungs. Acute arsenic poisoning can occur through ingestion of contaminated water, occupational exposure and deliberate poisoning. Acute Arsenic Poisoning: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis